Gut Reaction is the Health Data Research Hub for Inflammatory Bowel Disease (IBD) – one of seven hubs set up by Health Data Research UK (HDRUK) utilising health data to address major health challenges.

Led by Cambridge University Hospitals NHS Foundation Trust and funded by HDRUK, Gut Reaction is a resource available to everyone – researchers, clinicians and patients.

IBD includes Crohn’s disease and ulcerative colitis. Together, these conditions affect around 500,000 people in the UK. They cause recurring abdominal & bowel symptoms, and can cause problems outside the gut, affecting the joints, eyes or skin. IBD needs long-term treatment (often major surgery), and can significantly affect the lives of those who live with it.

Gut Reaction aims to build on the high-quality health data in the NIHR IBD BioResource by combining it with ‘real-world’ data from participating NHS hospitals and the IBD Registry. This will allow researchers to use the pooled data to support important research into IBD.

Gut Reaction is working with hospitals, industry and, most importantly, patients to create a unique, secure data resource for scientists in order to speed research for people living with IBD.

The Hubs are funded by UK Research and Innovation (UKRI) and the Medical Research Council (MRC), through the Industrial Strategy Challenge Fund (ISCF).

The partners involved in Gut Reaction are:


  • Cambridge University Health Partners

  • Cambridge University Hospitals NHS Foundation Trust (lead institution)

  • Crohn’s & Colitis UK

  • Eastern Academic Health Science Network

  • Leeds Teaching Hospitals NHS Trust

  • Manchester University NHS Foundation Trust

  • Microsoft

  • Newcastle upon Tyne Hospitals NHS Foundation Trust

  • NIHR BioResource

  • Pennine Acute Hospitals NHS Trust

  • Privitar

  • Royal Devon and Exeter NHS Foundation Trust

  • Royal Liverpool and Broadgreen University Hospitals NHS Trust

  • Salford Royal NHS Foundation Trust

  • UK IBD Registry Ltd

  • University of Cambridge

  • University College London Hospitals NHS Foundation Trust

  • Western General Hospital, Edinburgh